Prealbumin
This product is used on NEPHSTAR® protein analysis system for quantitative determination of human Prealbumin (PAB) in serum
Prealbumin is an acute phase protein that has a high affinity for and binds with both thyroxine and retinol binding protein. It is primarily synthesized in the liver, but is also produced by the choroid plexus. Increased levels are found in prednisone therapy and glomerular and tubular proteinuria. Decreased levels are found in severe liver diseases, malnutrition, congenital deficiencies, parturition and large doses of salicylates.
Immunonephelometry is applied. This method involves measuring the light scattered by insoluble complexes formed by reaction between specific protein in samples and its respective antiserum, and the amount of scattered light is directly proportional to the concentration of the protein under condition that antiserum is in excess. Concentrations are automatically calculated by reference to a calibration curve stored in the instrument.
Deutsch E, Geyer G, Wenger R, Laboratoriumsmedizin. Normalbereich der Ergebnisse und Interpretation abnormer Befunde, 3rd ed. Basel/Munich: Karger 1992.