Haptoglobin
This product is used on NEPHSTAR® protein analysis system for quantitative determination of human Haptoglobin (HPT) in serum
Haptoglobin is a kind of acute phase protein in blood plasma which binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system. In clinical settings, the haptoglobin assay is used to screen and monitor hemolytic anemia Increased levels of HPT are reported in acute inflammation, nephrotic syndrome, collagenoses, coronary disorders, Hodgkin’s disease, and tuberculosis. Decreased levels of HPT are found in haemolytic anaemia, liver disease and acute malaria.
Immunonephelometry is applied. This method involves measuring the light scattered by insoluble complexes formed by reaction between specific protein in samples and its respective antiserum. The amount of scattered light is directly proportional to the concentration of the protein on condition that antiserum is in excess. Concentrations are automatically calculated by reference to a calibration curve stored in the instrument.
1. According to CRM470, Normal range of HPT concentration of healthy adult is0.3-2.0g/L. We recommend local reference ranges are produced.
2. Diagnosis and treatment can not only depend on determination of HPT. The clinical symptoms and other laboratory findings of respective patients should be taken into consideration。