Ceruloplasmin
Ceruloplasmin is a copper oxidase enzyme, possible important in regulating the ionic state of iron and other metallic ions. Levels are decreased in hepatoenticular degeneration or Wilson’s disease and Menke’s Kinky hear syndrome. Levels are elevated by the acute phase response and particularly by estrogens.
Immunonephelometry is applied. This method involves measuring the light scattered by insoluble complexes formed by reaction between specific protein in samples and its respective antiserum, and the amount of scattered light is directly proportional to the concentration of the protein under condition that antiserum is in excess. Concentrations are automatically calculated by reference to a calibration curve stored in the instrument.
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3. Poulik, M. D., and Weiss, M. L., in F. W. Putman, Editor, “The Plasma Proteins”, vol. 2 second Edition, Academic Press, New York, pp. 52 – 108.