Calprotectin (Serum)
The described Calprotectin ELISA kit is intended for measurement of (MRP8/14, S100A8/A9) in serum, EDTA-plasma and urine.
Summary
Calprotectin is a calcium-binding protein secreted predominantly by neutrophils and monocytes. The heterocomplex consists of the two proteins, S100A8 (calgranulin A) and S100A9 (calgranulin B), also designated as MRP8 and MRP14, respectively.
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References
- Striz I, Trebichavsky I: Calprotectin – a pleiotropic molecule in acute and chronic inflammation. Physiol Res 2004, 53: 245-253.
- Yui S, Nakatani Y, Mikami M: Calprotectin (S100A8/S100A9), an inflammatory protein complex from neutrophils with a broad apoptosis-inducing activity. Biol Pharm Bull 2003, 26: 753-760.
- Odink K, Cerletti N, Bruggen J, Clerc RG, Tarcsay L, Zwadlo G et al.: Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature 1987, 330: 80-82.
- Wilkinson MM, Busuttil A, Hayward C, Brock DJ, Dorin JR, Van H, V: Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues. J Cell Sci 1988, 91 ( Pt 2): 221-230.
- Muller F, Froland SS, Aukrust P, Fagerhol MK: Elevated serum calprotectin levels in HIV-infected patients: the calprotectin response during ZDV treatment is associated with clinical events. J Acquir Immune Defic Syndr 1994, 7: 931-939.
- Hermani A et al. Calcium-Binding Proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer. Clin Cancer Res 2005, 11: 5146-5152.
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