C-Reactive Protein Assay Kit (CRP)
For the in vitro quantitative determination of CRP in serum or plasma samples.
CRP (C-reactive protein) is an acute phase protein whose concentration is seen to increase as a result of the inflammatory process, most notably in response to pneumococcal (bacterial) infectious, histolytic disease anda varietyof disease states.Originallydiscovered by Tillet et al. in 1930 in patient sera with acute infection, CRP has now come to be used as a marker or general diagnostic indicator of infections and inflammation, in addition to serving as a monitor of patient response to therapy and surgery. Furthermore, regular measurements of CRP in infants can be a useful aid in the early diagnosisof infectious disease.
When an antigen-antibody reaction occurs between CRP in a sample and anti-CRP antiserum, agglutination results.This agglutinationisdetectedasan absorbance change (340 nm), with the magnitude of the change being proportional to the quantity of CRP in the sample. The actual concentration is then determined by interpolation from a calibration curve prepared from calibrators of known concentration.
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