Beta 2 Microglobulin
This product is used on NEPHSTAR® protein analysis system for quantitative determination of human Beta 2 Microglobulin（BMG） in serum
Found on the membranes of virtually all body cells, BMG is a low molecular weight (11,800 Daltons) protein and a component of HLA class I light chain. Free BMG is a product of cell breakdown. It is secreted by the renal glomeruli, then absorbed and catabolized by the renal tubular cells. Decreased glomural filtration is associated with high serum levels of BMG, whereas tubular insufficiency is associated with normal serum and high urine levels. Markedly increased cell breakdown, as in acute leukaemia, may also be associated with high serum levels.
Immunonephelometry is applied. This method involves measuring the light scattered by insoluble complexes formed by reaction between specific protein in samples and its respective antiserum. The amount of scattered light is directly proportional to the concentration of the protein on condition that antiserum is in excess. Concentrations are automatically calculated by reference to a calibration curve stored in the instrument.
1. Normal range of BMG concentration of healthy adult in sera is lower than 2.5mg/L or no more than 0.25mg/L in urine. We recommend local reference ranges are produced.
2. Diagnosis and treatment can not only depend on determination of BMG. The clinical symptoms and other laboratory findings of respective patients should be taken into consideration。