Albumin
This product is used on NEPHSTAR® protein analysis system for quantitative determination of human Albumin (ALB) in serum
Albumin is an single nonglycated protein, it has a molecular weight of 66KD. Albumin is synthesized by hepatic parechymal cell and the synthesis rate is 14g per day. Albumin normally constitutes about 60% of human plasma protein, it is called microalbuminuria when a little abnormal albumin present to urine, albumin also is a marker protein of all kinds of albuminuria. Albumin plays an important role in maintenance of serum osmotic pressure, as well as the transport of various substances. Decreases in serum albumin are observed in the following conditions: liver diseases, excessive secretion in urine (kidney diseases), flux of serum proteins from inside blood vessels and malnutrition. In addition, greatly reduced albumin levels may also result from a genetic deficiency.
Immunonephelometry is applied. This method involves measuring the light scattered by insoluble complexes formed by reaction between specific protein in samples and its respective antiserum, and the amount of scattered light is directly proportional to the concentration of the protein under condition that antiserum is in excess. Concentrations are automatically calculated by reference to a calibration curve stored in the instrument.
1. Deutsch E, Geyer G, Wenger R, Laboratoriumsmedizin. Normalbereich der Ergebnisse und Interpretation abnormer Befunde, 3rd ed. Basel/Munich: Karger 1992.