α1-Antitrypsin
This product is used on NEPHSTAR® protein analysis system for quantitative determination of human α1-Antitrypsin (AAT) in serum
α1-Antitrypsin is an acute phase protein. It inhibits proteinase and serine proteases. AAT has a strong binding constant for leukocyte elastase. Increased serum levels are found in acute infection and inflammation, advanced malignant tumours. Decreased serum levels are found in congenital deficiencies, juvenile cirrhosis, lung emphysema, testosterone administration.
Immunonephelometry is applied. This method involves measuring the light scattered by insoluble complexes formed by reaction between specific protein in samples and its respective antiserum, and the amount of scattered light is directly proportional to the concentration of the protein under condition that antiserum is in excess. Concentrations are automatically calculated by reference to a calibration curve stored in the instrument.
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