α1-acid glycoprotein
This product is used on NEPHSTARTM protein analysis system for quantitative determination of humanα1-acid glycoprotein (AAG) in serum
Human α1-acid glycoprotein (AAG) is a plasma acid glycoprotein of molecular weight 40 000, rich in carbohydrate and synthesized by the liver. It is an excellent protein to assay along with haptoglobin in assessing in vivo hemolysis. An elevated AAG level but normal haptoglobin suggests an acute phase response with mild to moderate in vivo hemolysis. As an early acute-phase protein, increased blood levels of AAG have been known for many years to be associated with inflammation, cancer, cardiac infarction, trauma, pregnancy and rheumatoid arthritis. High level of AAG is also regarded as one of the most reliable auxiliary diagnosis indexes for active ulcerative colitis. Decreased levels are reported in malnutrition, severe liver injury and nephrotic syndrome. The usage of estrogen may reduce it.
Immunonephelometry is applied. This method involves measuring the light scattered by insoluble complexes formed by reaction between specific protein in samples and its respective antiserum, and the amount of scattered light is directly proportional to the concentration of the protein under condition that antiserum is in excess. Concentrations are automatically calculated by reference to a calibration curve stored in the instrument.
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