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Ischemia modified albumin Assay Kit (IMA)

For the in vitro quantitative determination of Ischemia modified albumin in serum.

Regulatery Status: CE

Product Catalog Number Packaging Method/Format
Product Catalog No: Kit (80 Ml) Pack Size: GS271X Pack Size: R1: 1 × 60 ml
R2: 1 × 20 ml 		Pack Size: Albumin-cobalt Binding
Product Catalog No: Kit (80 Ml) Pack Size: GB270X Pack Size: R1: 1 × 60 ml
R2: 1 × 20 ml
Product Catalog No: Kit (80 Ml) Pack Size: GX271X Pack Size: R1: 1 × 60 ml
R2: 1 × 20 ml
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Product Features

Ischemia modified albumin is produced when N-terminal amino acid of albumin is modified by copper ion or others. This situation occurs when a tissue is ischemia or reperfusion occurs. IMA is a early warning indicator before cell necrosis occurs in myocardical ischemia.The elevation degree can indicate the degree of myocardical ischemia. In clinic, IMA is a potential use in early diagnosis for acute myocardic ischemia(AMI) and acute coronary syndromes(ACS).

Assay Principle

After IMA in sample conjugates with cobalt ion, the color developing ragent conjugates with cobalt ion else to produce a red material.By the standard curve,calculate the IMA concentration in sample.

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References
  • Bar-Or,D.,etal.,CharacterizationoftheCo2+ andNi2+ bindingamino-acidresiduesoftheN-terminusofhuman albumin.EuropeanJournalofBiochemistry,2001.268(1): p.42-48.
  • Sinha,M.K.,etal.,Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention.Circulation,2003. 107(19):p.2403.
  • Bar–Or,D., E.Lau, and J.V.Winkler,A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia—a preliminary report.The Journal of emergency medicine, 2000.19(4):p.311-315.
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