Anti-cyclic citrullinated peptide Assay Kit (Anti-CCP)
For quantitative determination of Anti- cyclic citrullinated peptide (Anti- CCP) in human blood.
Cyclic citrullinated peptide(CCP) antibodies are autoantibodies produced by rheumatoid arthritis (RA) patient that are directed against cyclic citrullinated peptides (CCP). It is an important indicator of early diagnosis RA. The CCP antibody test helps to diagnose early RA: CCP antibodies can be detected as early as several years before the typical clinical symptoms. The sensitivity and specificity of CCP is superior to RF. CCP antibody testing, along with RF, could improve the detection rate of RA.In recent years, the bone destruction of positive patients is more serious than negative patients according to the study. Additionally, high concentrations should suggest poor prognosis and high risk of joint erosion. Thus, it is an reliable indicator of observing patients condition and using of drugs.
Agglutination is formed when CCP antibody is reacted with latexparticlescoated with hypersensitized CCP antigen. The rate of formation is proportional to the concentration of Anti-CCP in the samples and is measured colorimetrically as in increase in absorbance at 546 nm.
- MILNE, Ken. Assay method for antibodies against cyclic citrullinated peptide: WO 2009/103988 A1.2009-02-20.
- Xu Miaogen. The value and application of Anti-CCP antibody in patients with rheumatoid arthritis. J of Radioimmunology 2013, 26(6):756-758
- The meaning ofAnti-CCP antibody in patients with rheumatoid arthritis. Chinese Journal of Clinical Laboratory Science, 2004, Vol 22, No.213