ApolipoproteinA1 Assay Kit (APOA1)

Lipids are metabolised in the intestine or liver, and are transported to tissues and organs after hydrophilic adaptation by a series of micellar structures. These structures consist of an outer monolayer of protein (an apolipoprotein) and polar lipids (phospholipids andunesterified cholesterol) plusan inner core of neutral lipids (triglycerides and cholesterol esters). The apolipoproteins interact with a series of enzymes and tissue receptors and are therefore responsible for further metabolism and catabolismof the micelle. The A apolipoproteins are the main form of protein found in high density lipoproteins (HDL), although chylomicrons are also present. The main role of apolipoprotein AⅠis in the activation of Lecithin cholesterol acyl transferase (LCAT) and removal of free cholesterol from extra-hepatic tissues. Apolipoprotein AⅠmay therefore be described as non-atherogenic, showing an inverse relationship to cardiovascular risk. Studies have shown that there is an inverse relationship between Apo AⅠand coronary artery disease and a direct relationship with Apo B such that patients with CAD have generally reduced levels of Apo AⅠand increased levels of Apo B.